Chang Jim

I have a question regarding to mileage. If my purpose is to get more mileage from the flights, will it be helpful to take flights with more transfers or that doesn't matter at all as it only calculate the distance between origin and destination?

For example, if I fly from A to B, needlessly to say direct flight will be faster and shortest. Will I get more mileage to my frequent flyer account if I buy the ticket that has more transfer, like A-C-B (one transfer) or A-C-D-B (two transfers)?

Thanks!