I'd rather not socialize on an airplane. Just because the computer plunked us in adjacent seats for a few hours I don't feel compelled to tell you my life story nor am I particularly interested in yours.
The one exception was YYZ-TPA about a week after the 9/11 restrictions were lifted. My seatmate was a woman about my age who told me that she was very frightened. We chatted for the entire flight about nothing important and when we landed she thanked me for helping make the flight easier for her.