Moderator, Marriott Bonvoy & FlyerTalk Evangelist
Join Date: Oct 2002
Location: McKinney, TX, USA
Programs: United Silver; AA Plat/2MM; Marriott LT Titanium; Hilton Gold
Posts: 11,773
As long as your stay is contiguous nights, then yes, you will be able to use a 5th night free award in conjunction with some paid nights.
So if your stay is 7 nights, and the 2nd and 5th nights are paid, the other 5 nights can be paid for using a 5th night free award.