Hotel for combination of location and cleanliness. In certain situations I can't avoid the Travelodge/Super 8 level (if everything else is 2.5-3x the cost, don't be foolish), but if at all possible I'm gunning for at least a newer Fairfield or HI, preferably a SpringHill Suites or Residence Inn with places to eat/drink/buy said food or drink within walking distance. Huge bonus points if reliable mass transit is available too.
I've been traveling for a while to get where I'm going. I want to easily stock the fridge if I'm feeling antisocial, or walk over to somewhere that serves local beer and enjoy several of the bartender or waiter's recommendations with car keys safely locked away if I feel like going out.