A girlfriend and I did self drive earlier this year. We took the Panoramic route up... it's gorgeous!

As we cut over to Kruger on the north end, we stopped at a game rehabilitation center (Mahalolo??) that was a highlight, too.

The Panoramic route had some very impressive potholes, especially on the southern section. I wouldn't tackle it at night because you might fall into one of them!

We did Skuzuka (a bit hard to find with just a map), Rhino Post, and several Sanparks rest camps. It was a terrific trip. I'm still talking about it and can't wait to go back!