I bought my tickets yesterday. Two friends and I will be taking a GUA-CCS route for the 500k bonus. I was mighty tempted to go for the full 1M, but this plan seems less expensive per mile--at least when flying full fare or business. The full Y cost for this routing is under $1,200 (plus 25k AAdvantage miles to get in & out of South America).
We've got several days planned in Bonaire at the end of the trip. That gives us some slack if some of the flights get delayed or cancelled. If all goes as planned, we'll get the 500k miles in a fairly comfortable fashion and have a nice diving vacation to boot.
I'll take a $118 SFO-LAS-SFO trip on National for the partner segments.
If the miles post in the timeframe LatinPass promised, we might use miles from the first 500k to get the last 500k for under $1,000.