No problem.
I could probably get 4 nights of pants/shirts/undershirts/boxers/socks in using folders and cubes, but there's no way I could do 4 nights with an extra pair of shoes. One drawback I am noticing is that my pants bunch a bit at the sides of the waist (folded along the crease) when packed... I'm a 38 waist, so maybe I need to get down to a 36 to fix that!