F9 doesn't fly CLE-ORD or CLE-MDW. While I could see CLE-ORD doing well, I have doubts that it would start this route as F9 has avoided the just under six hour by drive according to google maps routes. Google maps estimate, of course, expects no stops in the drive.

Otherwise it would have launched TTN-PIT initially instead of TTN-CMH which was a dud. Yet, the six hour routes can have high demand since ties are going to be stronger to the region six hour away rather than a medium market region that's farther.

I could see it trying CLE-MKE however, as there is no LCC on the route, it's longer, and some might fly to use it to get to Illinois.

It also doesn't fly CLE-LGA or JFK. I think chances are even lower for CLE-New York because of the slot pair hassles. Also, Southwest is offering low fare service via CAK.

It does launch CLE-DFW. I think CLE-IAH and CLE-AUS might be future routes it adds, but maybe don't expect it, especially not service to New York or Illinois.