Originally Posted by Sjoerd

Which of your flights from A to B (on a scheduled commercial flight that is (or was) bookable by all) is so uncommon that you expect no other Flyertalker has ever flown this route?

I'll start: RTM to CFN: Rotterdam to Donegal which was a weekly scheduled route on VLM Airlines (merged with Cityjet in 2010) during the summer of 2008 operated on Fokker 50s.