Just got back from a 12 hour CW flight this morning, my third A380 round trip since Christmas.... And I'm shattered, no sleep again. I much prefer the 747 UD.
These are my main issues.
The cabin temperature is so cold. Frozen nose

The food service is slow and very spaced out between courses.
The plane is so quiet that the cabin is actually noisy! All normal noises seem amplified .. Galley noise, passengers sniffling, snoring, talking etc.
Oh... The toilet is great though