For airlines

1. Stash up on AA miles. try to get 3 more AA cards if possible and you will have at least 530k AA miles which will allow you to travel to first/business around the world.

2. Obtain some avios from either Chase UR Cards. For short hauls when you are within the region. And to cross regions.

You could do

US-South America Zone 2 Economy Off Peak 20k
South America Zone 2 - South Pacific (Australia) - Africa - Asia - US Business (50+50+50+55) = 205k AA

For total of 225k AA miles, without major taxes/fees surcharges. Use extra miles for travel within regions using AA miles e.g. 10k one ways within Africa, South America, Asia 2 etc.

However, for Africa, I would try to get some miles to use on star alliance esp. because oneworld/AA doesnt have good coverage there.