Professional simply means it would be appropriate for use as an everyday business bag, obviously not for sport backpacking. The level of 'professional' applies to the look -- are you an IT professional or a Goldman Sachs investment banker? A passenger next to me on a flight yesterday had this Tumi, good for either.
She said she got it because her previous Tumi lasted 14 years. $445
Perhaps not
quite that durable, but looking very tough, another passenger deplaning in front of me had this. I asked him how he liked it and he absolutely loves it. $55. Not as buttoned-down a look as the Tumi, (I would doubt this would work at Goldman

) but at $55 it looks like a great value proposition. (Let's face it, Tumi is GREAT stuff, but much of the price is for the name).
Link with organization photos here:
http://www.amazon.com/Targus-Drifter...YGZX1RXQZJRN8G
Somewhere in the middle, at $279, also probably brute tough, but more reasonably priced than the Tumi is this Briggs & Riley. Probably good for either the IT tech or the boardroom.
http://www.ebags.com/product/briggs-...uctid=10264359