Nothing that extreme...
I routinely will fly SAN-LAX/SFO-JFK instead of SAN-EWR for the business class product LAX/SFO-JFK. This probably adds another 5 hours of travel time between the connection, layover and extra driving time.
Last year, I flew SAN-DEN-NRT to catch the 787 DEN-NRT. This only added a few extra hours instead of the more traditional SAN-LAX/SFO-NRT.