What side should luggage open on? I have suitcases that open on the right, and suitcases that open on the left. As I am right handed, when I think about this, it would seem to me that I would grab the top handle with my right hand, and then the bottom with my left, so that would seem to indicate that the opening should be on the left side. But when I do that it seems really awkward to me, I find I default to putting the handle to my right when I lay my luggage down on a surface to open it up.