I'm sure I've had noisy neighbours on flights but I tend to just Scotch myself into a coma if I'm getting annoyed with cabin noise.
I've had a bloke who was incessantly playing with the CW divider for a good 15 minutes of up-down-up-down-up-down before I asked if he'd like me to rip it out so he could take it home with him.
I'm "that guy" who doesn't think twice about taking his 3 month old and 3yr old children into F, so kids on board don't tend to bother me at all.
Weirdest passenger experience was a guy who popped a few pills sat next to me in J before a 10 hour night flight, and was passed out 30 minutes later. Unfortunately the plane went tech and he had to be pretty much carried off.