I think LAS is a great place to minimise jetlag. Figure out what time zone you want to be on and spend your last day or two accordingly. Vegas is a 24 hour place, so you can happily stay on any time zone you like.
For some that might mean staying up most of the previous night, and getting their head down soon after boarding, for others it might mean a meal on board, then sleeping all the way through to landing.
Mind you, if I didn't have to be anywhere for 2 days after returning, I wouldn't be worrying too much about conquering jetlag. Unless you get it very badly, you shouldn't have problems after that whatever you do.