I loved the Boscolo in Prague. It's in a great location which is a 3-4 minute walk from the bus station for the Airport Express (AE service) which costs just 60czk each way. It's also close to the Jindrisska tram stop or the Namesti Republiky subway so great for getting around.
The suite was great with high ceilings, a Nespresso machine in the room and breakfast was superb. I stayed on a MR exclusive suite upgrade rate which was good value.