I believe the rental car surcharge is dependent on where you pick your car up, not where you drop it off. Some companies do charge extra, however, if you drop off at a different location than where you picked up.

The easiest way to check is to go to a couple of rental car sites such as Hertz.com (or Budget or Sixt or Europcar) and just enter in details. In 5 minutes you can have an idea if the surcharges are a big deal or no big deal for you.