RP/OP availability will be still the great limiting factor.
On KL has to be on Y, B or M.
On AF only valid for flights from US48 to CDG and not any others, and still the same fare class restrictions.
HNL-ATL flights need global upgrades, not regional, and even JFK-LAX/SEA/SFO need global and not regional.
Mileage upgrades still require Y, B or M fare class.
All in all, a yet another "enhancement" that brings little positive (any fare class but E on DL flights), but still more negative (less certs, and now only for DMs).
The one other improvement is "Medallion Complimentary Upgrades eff. 3/1/14: Between Hawaii and LAX, SEA, SFO, or SLC", but that is not PU503 (or whatever the new global upgrade certs will be equivalent) specific.