I like to travel light, and after a dozen 2 day work trips using a backpack, decided I wanted a nicely sized overnight bag with rollers for those inevitable standing-in-line periods.
I'd heard really good things about Briggs and Riley's warranty from a coworker, and picked up the little Transcend TUC115. I love it so far. It's perfect for 1-2 day work trips (fits my 13.3" laptop plus a couple changes of clothes and toiletries) and is organized really well. I also like that it's not divided down the middle, and just has one big opening that opens up nice and wide for packing.
It's not ideal for everyone, but if you like traveling small and light, it's worth a look.
http://www.briggs-riley.com/category...115&sec=travel