The most significant changes I can see that will hurt is the last sentence of 3.2.1.
FOR TRAVEL ORIGINATING IN AFRICA ONE OF THE
FOLLOWING BACKTRACKS IS PERMITTED.
3.2.1 //AFRICA-EUROPE-RTW-EUROPE-AFRICA//
ONE OF THE VISITS TO EUROPE MUST BE A
TRANSFER WITHOUT STOPOVER BETWEEN AFRICA
AND THE PREVIOUS/NEXT CONTINENT. TRAVEL
MAY NOT INCLUDE MAURITIUS/SOUTH AFRICA.
This means that we can no longer start in SA and finish in NBO (or similar) with two passes through Europe.
My current RTW now shows as invalid as I started in JNB and will finish in NBO with one stop and one transit without stop in Europe.
From my understanding of this if you start in SA or MRU you will always have to go via Asia without visiting the rest of Europe in one direction of travel if you want to visit Europe the other direction.
Also 3.2.3. No ME sector from/to Europe if you start in Africa.
These things are becoming more and more restrictive and more and more expensive.