I once did an interesting combo with Amanpulo, a night in Manila, then a week at the Palau Pacific Resort - that's in Palau, an independent state in Micronesia. Extraordinary place. The hotel is excellent but not luxury in the terms of this Forum. Then I came back via Hong Kong.
Personally, I think a lot of these SE Asian beach resort areas like Phuket, Bali and so on have lost their charm and interest for me. However, I'd go back to Amansara at the drop of a hat.