My first post gave Itin A:

ITIN A
Leave HNL 6:17 AM. Have lie-flat J seat in UA 767-400ER. (Need to wake up really early to catch this flight!)
Arrive SFO 2:30 PM
Leave SFO 7:20 PM In new F suite UA 747
Arrive FRA 3:00 PM (next day)
Slight change:
FRA to IST on TK J A330, departing 6:30 PM
Arrive IST 10:25 PM

Alternatives may be available:

ITIN B
Leave HNL 8:25 PM, Have lie-flat AC 767 J sleeper seats
Arrive YVR 5:05 AM
Leave YVR 4:15 PM on LH F A340-600 (old F seats)
Arrive FRA 11:10 AM
FRA to IST on LH, departing 1:00 PM on A321
Arrive IST 4:50 PM

ITIN C
Leave HNL 10:10 PM to DEN, either F or J seats are possible (3 cabin)
Arrive DEN 8:44 AM
Leave DEN 5:35 PM on LH 747-400 with new F seats/bed combo
Arrive FRA 11:05 AM
FRA to IST on LH, departing 1:00 PM on A321
Arrive IST 4:50 PM

Which itin would you select and why? Which itin do you think would provide the best sleep/wake cycle options?

Many thanks for your thoughtful advice!