Here's a starter list of candidates, assuming a "destination" means a resort with activities:

Marriott's Villas at Doral
Sawgrass Marriott Golf Resort & Spa
Hutchinson Island Marriott Beach Resort & Marina
The Lodge and Spa at Callaway Gardens,
Atlanta Evergreen Marriott Conference Resort
Griffin Gate Marriott Resort & Spa
Gaylord Texan Resort & Convention Center
Auburn Marriott Opelika Hotel & Conference Center
Courtyard Hutchinson Island Oceanside/Jensen
Courtyard Kaua'i at Coconut Beach
Courtyard King Kamehameha's Kona Beach Hotel
World Golf Village Renaissance St. Augustine Resort (Cat 4)
Lincolnshire Marriott Resort (Cat 4)
MeadowView Conference Resort & Convention Center (Cat 4)
Dallas/Fort Worth Marriott Hotel & Golf Club at Champions Circle (Cat 4)

Not in the US, but might be closer than US-based depending on your location
The Algonquin Resort St. Andrews by-the-Sea