It depends. I *like* driving a lot (see user name

) but spending hours on a motorway isn't that wonderful either.
Within the UK I'd probably go with rail most of the time just because I find it more relaxed than faffing with airports. I'm near enough to London to make train travel out of there feasible.
One thing I will always do is take the car to Belgium and fill the boot with beer to bring back.
France with a ferry crossing to somewhere other than Calais is an option I quite like as well.
Ultimately it's timings and schedule that dictates rather than preference though so if it's something that can be done within one day flying will probably win out.