Absolutely. We used both, and while we liked the Trenitalia ride better than Italo, it probably had something to do with the fact that Italo ran 90 minutes late and our car had a large group of lively 10-year-old boys running around.

A few days after our journey, Italo sent an email which said that we were due a 25% refund of the fare because of the delay, either in the form of a credit toward a future ticket, or a wire transfer to a bank account. Since we have no current plans to return to Italy, I called them when we returned home, and the wire transfer took about a month. ^