In Memoriam, FlyerTalk Evangelist
Join Date: Jul 2002
Location: Durham, NC (RDU/GSO/CLT)
Programs: AA EXP/MM, DL GM, UA Platinum, HH DIA, Hyatt Explorist, IHG Platinum, Marriott Titanium, Hertz PC
Posts: 33,856
On some planes it does make a difference. On the AA MD-80 in First, the EF side has slightly more legroom than the AB side due to the positions of the bulkhead.
Also, flying into certain cities like PHX, SAN and LGA I prefer the AB side for the view while flying out of JFK I prefer the EF/HJ side for the same reason. It all depends though, usually I just look for the seat I want (e.g. exit row window, closest window to the front) and take that no matter what side it's on.