Couldn't care less about the airframe, I care about the cabin interior. Put me in an Emirates suite on a 707, and I'll take that over a coach seat on a 787 or A380, any day of the week.

As for safety, commercial air travel is so incredibly safe that any variation is just noise - the difference between having a 1 in 100 million risk of dying and a 1 in 125 million risk is essentially zero.