Originally Posted by
AdamAuxier
As a MSP based flyer:
AA is best if you travel to Latin America.
UA is a solid choice to Latin America, both through its ORD/IAH hubs and - especially - on the *A partners Copa and Avianca. Copa flies nonstop from ORD to PTY; from PTY, you can connect virtually anywhere in Central or South America.
Originally Posted by
AdamAuxier
Downside is UA has shrunk MSP to DEN, ORD, EWR and IAD to all regional jets

UA still flies mainline jets MSP-ORD. But it is true that United increasingly relies on RJs to nonhub airports (such as MSP).