if most of your manufacturing occurs with the card issuers offering the best sign-up bonuses or you're trying to leverage 0% BT offers on some cards while manufacturing spend on others, your overall, card-level, and issuer-level utilization as reported on statements and to credit bureaus might be something to keep tabs on.
specifically, the timing of transactions posting, payments posting, payments restoring your available credit, payments being due, statements closing, and issuers reporting your utilization to credit bureaus is something i track pretty closely.
i'm sure most of us here pay off our balances before the due date, but timing can get tricky for those of us who are also aiming to keep all but a few cards from reporting any balance in the first place.