I love weekend trips, and I wanted to add to my earlier comment.

I have a lot of time to travel (20 vacation days + 13 holidays), and I tend to save my mileage balances with loyalty programs for the big trips (Brazil, Israel, Cambodia). I've a bunch of secondary program balances that I use for weekend trips (Thanks You Points, US Bank Flex Points, JetBlue, Spirit, and I'm willing to use the Skymiles Pay with Miles option since SkyPesos are so useless). If I were in your shoes, I would look into spending my WN points balance first.

I don't love sitting on airplanes that much, so unless I can't help it, I'll only fly direct on weekend trips. (I made an exception for Key West this year). I think the first step for you would be making a list of all the places you can travel to efficiently from ERI, and then start tracking those fares and checking mileage availability.

I've also found that it's easiest to organize trips to big airports. When I travel, I want to leave the office, go to the airport and maximize my time on the ground. That's easy to do if you're heading to a busy airport. It's a bit harder when I want to go to a place with less frequent service.

My recent and planned weekend trips out of NYC:
*Tampa
*Key West
*San Juan, Puerto Rico
*Western Puerto Rico (flew into BQN)
*Mexico City
*Pittsburgh and Fallingwater (loved Fallingwater! that trip to PA was one my best travel experiences of 2012)
*Los Angeles
*Washington, DC (on Amtrak)
*Philly (on Megabus)
*Lancaster, PA and Amish Country (on Amtrak)
*Newport, Rhode Island (on Amtrak)

The northeast trips (Pittsburg, DC, Philly) were all on regular weekends. The rest were on long weekends. I really hate the cold, so a lot of my travel is focused on escaping the NYC winter. Your convenient trips will be a bit different, but hopefully the list is a bit of inspiration.