MDE-BOG is blocked at right around one hour (actual flight time usually in the 30 minute neighborhood). For AV, this is an extremely high frequency corridor/shuttle style market with at least one departure an hour each way (often more).

Barring a volcano erupting and spewing enough ash clouds to shut down Colombia's airspace, I don't think there's an airline in the world that isn't sufficiently reliable to get you there. Any airline that can't perform on this really ought to just give up, cut up their airplanes and turn them into Coca-Cola cans!

You could probably walk from SKRG to SKBO and still make a 23:55 departure given that you are willing to spend all day just to travel a couple hundred miles.

What you are asking is the equivalent of worrying about flying QF out of MEL at noon to make a connection out of SYD at midnight.