Last direct HKG-Macau sailing is at 10p. What time is your scheduled arrival? After that you can still go to HK Island and transfer, but that means very late getting to Macau.

Anyways, I generally suggest two nights in Macau. Hotels are much cheaper in Macau than Hong Kong; but they are also much lower Sunday to Thursday than Fri/Sat, while in HK, weekends may be a little bit cheaper than weekdays, especially in the top hotels. But that may not work for you if you arrive HKG late on Wed. Anyways, Thursday night in Macau is a given. Whether you want to add Wed, Fri or neither depends.