I've never been uncomfortable as in "OMG We're Going To Crash" on a CRJ but I am often uncomfortable as in "Who The @#*$ Designed These Torture Seats". I don't have this problem with Embraer jets. They're small but the seats are at least comfortable.

That said, FC seat 1A on the CRJ700 and CRJ900 is an excellent seat if you can manage it.