I have been in complete agony on one flight and the next one a few hours later is fine. I wish I could pinpoint the triggers for the pain but after years of flying I have yet to do so. You should absolutely use the ear planes for the entire flight, they really do seem to make a difference. I have had good luck with the mucinex 1200 but since you will be on a red eye there is the potential for that product to keep you from sleeping. Best of luck on you next flight!