I've had no problems. I've been applying for credit cards for a bit over a year now. My score was around 790-800 and my wife's around 750, and I don't think either of our scores has really moved. We don't do AOR's, I tend to apply for a new card every 2 months or so. But maybe these credit pulls interact with other credit factors differently for different people.

Even if they lowered my credit score, I would still feel like "so what?" I don't get a free dessert with my entree at the local steakhouse for having a high credit score. It's there to be used.