Originally Posted by Consultette

Staying near North Hollywood would give you access to both the Orange Line and the Red Line subway. You can take the red line to Hollywood and Downtown. There is a great area around there called "Toluca Lake" where some of my coworkers live (married couples in their early 30s with no children). The NoHo arts district will give you stuff to do within walking distance and easy access to both the Orange Line and Metro Red Line (subway through Hollywood toward Downtown) for your wife if you have to take the car during the day.