I usually check the one-way route as well as the round trip because, unless they've changed their system in the past couple of years it's generally more likely to get the one-way route on FF and then just book the other one one-way and pay for it as normal (usually booking 2 tickets at once).
For example: We fly SEA-OMA a couple of times a year, and I noticed that the availability for Seattle to Omaha on Frequent Flier at the lowest tier is a lot more likely than the Omaha to Seattle. (A lot more people trying to get into Seattle than out of it? ;p) I'm glad the system is flexible enough to make it easier to make arrangements one-way for half the miles, it makes the miles much more useful in those scenarios. (I don't tend to have a really high balance, probably hover around 42k miles at the most)
What happens when you check for a round-trip FF and it has the low tier availability for one-way only and the higher tier for the way back? Will it let you mix the two or will it hide availability of the one-way for the low tier (like it used to do prior to the FlyFrontier redesign)?