As a longtime resident of the Vancouver area, welcome, assuming you are taking the job out here.

Yes, quick trips to BOS, NYC, PHL, BWI/DCA and such will have to be replaced by SEA, LAX and SFO. Of course, SEA is more of driving destination than a flying one from here except for connections (primarily AS (Horizon Air)). There is also BLI (Bellingham, WA) that is more of an attractant for leisure travel but is also a much shorter drive the SEA and works for connections through SEA and Portland, OR (PDX).