I've sat in Rows 1,2,3 and 4 on the 380 and frankly, once you close the doors, I haven't noticed any difference.

Some try and avoid row 1 as it is right next to the curtain leading to the showers but it has never bothered me...people don't hang around outside your suite. And you can say you had row 1 on the 380!

If in row 4 with the door open you may hear some noice from the galley but with 3 crew members there, it's not likely to too noisy.

Just avoid the middle seats. Although they have a very good divider to give you privacy it's just more gloomy and you do not have the additional of the side window bins.