My trips are usually leisure, and I live out of my suitcase mostly out of necessity because I like staying in hostels, but I also don't like to scatter my things around.
Since it's a holiday, I do the sniff test for everything before putting it on. I do wash my underwear, socks and tights daily, and hang them out to dry. The rest either go through the sniff test, or into one of the extra packing cubes I have (the water-resistant one from Eagle Creek) for washing.
I travel alone and don't stay in one place for THAT long so nobody really notices. I also make my own linen spray so clothes don't stink all that much, I think.