All in all, not the most promising aspect for a hub.
I think there is some possibility that LY could capitalize on North American business traffic that has ties to Israel. For example, during off-peak periods USA-TLV and TLV-2ndary europe, LY could offer a fare that allows a 24-48 hour stopover in TLV enroute to europe.
I would certainly love to grab a day in Tel Aviv, with the added benefit that the long flight is longer allowing for more sleep than the 8 hour NY-Europe. It could add some nice marginal demand, if only a dozen people a day.