This may well not be to your taste, but just to put a different point of view:

We used to like the Mandarin Oriental - the view from some of their rooms is fabulous. We tried various others, including the W (which we walked out of after one night) and the FS (dull).

Eventually we twigged that San Francisco is far lovelier if you get right out of the business and tourist districts. So we found the Hotel Drisco up in Pacific Heights. This neighbourhood is where many of the zillionaires live ... tranquil, mostly tourist-free. The sort of area where you might see kids selling lemonade from a stall in their front garden, and people walking dogs. Wonderful restaurants not too far away too,

Hotel Drisco is below the "luxury" standards of most chain hotels covered in this forum - it's more like an independent mid-priced European hotel - but we found the service to be kind, personal and thoughtful; the rooms are comfortable; and there are little touches like wine or tea in the lounge in the afternoons. We loved it and have been back for both business and personal trips.