I know, random places. Right now looking to connect from Rome to Istanbul. We are touring Venice, Florence, Siena and Rome before we have a few days before we are supposed to arrive in Istanbul. Right now there are 3 flights are nearly the same price as FCO-IST:

FCO-MLA-IST
FCO-OTP-IST
FCO-SOF-IST

Any recommendations on which location to choose? With each place we will have 2 full days (as flights leave early morning). A little about my wife and I: love to explore, try local food and mingle within the locals.

Other suggestions are welcome as well! We'll be leaving Rome on a Tuesday in May and arriving in Istanbul on Thursday.

Thanks!