I'd say generally yes, but you'd want to check what the output of the wall/mains charger is as compared to the device. If it's 5 watts or less it's likely safe for most things (iPods, iPhones, Bluetooth headsets, etc.) Older iPods use less but generally are OK with chargers that have more wattage. Keep in mind that if you use it for something like an iPad which requires 10 or 11 watts to charge that it will take longer to charge one of those devices with a power adapter that has less watts.