I fly the IAD-CHO route regularly. The props definitely "feel" different than larger planes - you will experience more vibrations/bumps/etc due to lower atmosphere/smaller plane/slower speeds but they are absolutely, totally safe. Step up to the flight knowing it will be a bit different and enjoy the experience. And CHO ground staff are great - only place I've had phone calls on my cell when running late asking "Mr. RazorSoup, we just wanted to check if you were going to make the flight today." Happened twice in the last few years about 30 minutes prior to departure.