Welcome to FT.

Not sure what hotels you mostly stay in, but, when you check out the Marriott threads here on FT make sure to look at the travel packages they have. It's some of the best deals around for redeeming and air and hotel.

Another idea, if you are not interested in churning CC's, then you could think about a few different ones that are offering a good sign up bonus that are keepers and utilize those to earn points/miles as well.

Choosing 1 hotel chain or 2 (if your travel will support) to frequent seems to work for many. I am not certain how hotels.com could be the best program out there (I could be wrong, just doesn't seem to be advantageous to road warriors).

But, you definitely need to decide what your goals are and if you don't have any current plans, think about what you may like to do and work toward that goal.