I stayed at the Renaissance Prague in November. Location was convenient - walked from the train station to the hotel, and walked every day everywhere from the hotel. The rooms were nice and modern - yes, American style, but that was fine with me. Minibar, marble bath, data port, alarm... yep, all the things I needed. Breakfast buffet was fine if overpriced. Also, used hotel's private car service to the airport, nice that they have a fixed rate (either 600 or 800 CKc).