Well, TripTalker and I will be there March 10-17.. Will we overlap?
My advice would be to avoid the Hilton. It is an ugly musty atrium-type hotel with a dingy casino located in an inconvenient place across the freeway from the good stuff.
The Marriott and Renaissance are across the street from each other in a prety good location on the outskirts of old Prague. We stayed at the Marriott last year the first week it was open and had a good time. This time we're staying at the Savoy, an older hotel considered by some to be the best in Prague, for about $165/night including tax and breakfast. (Warning: hotel tax in Prague is 22%!