I do a couple of things. Typically I upload some to Picasaweb (Google's photo site) to share online.

Some of my favorites I print large and frame.

I have done a big month-long trip to Asia for the last several years. When I get back I make a photobook. I have used Blurb most often but have also tried Photobook America and MyPublisher. I always do the largest "coffee table" book size. They usually end up being 150-200 pages. Most of the time I go for the highest quality paper options that are offered. I enjoy flipping through them from time to time. My friends always rave about them. They're a nice way to have a collection of pictures and I add in some narrative which also ends up helping me remember the names of places visited and what happened. :-)